English
讲座编号：jz-yjsb-2019-y031
讲座题目：AOP based integrated approaches to testing and assessment for skin sensitization hazard and potency
主 讲 人：张全顺 美国体外科学研究院教育和外联项目科学计划主任
讲座时间：2019年06月05日（星期三）上午10:00
讲座所在：阜成路西校区314
加入工具：理学院化妆品专业教师和研究生、本科生
主办单位：研究生院
承办单位：理学院
主讲人简介：
张全顺，资深毒理学科学家，结业于南京农业大学，现任美国体外科学研究所（Institute for In Vitro Sciences，IIVS）教育和外联项目科学计划主任 。张博士曾在上海收支境检验检疫局从事产品毒理学检测及临床宁静评价事情，有十年的海关检疫事情经验，2000年赴美在普洛威顿斯学院和塔夫茨大学从事产品宁静检测和临床评价的研究事情，积累了富厚的化妆品产品研发，宁静和功效评价经验 。张博士曾担当塔夫茨大学的研究助理教授，积累了富厚的化妆品产品研发，宁静和功效评价经验 。目前他卖力的化妆品体外宁静功效评价教育和外联项目主要在中国，巴西和俄罗斯进行 。
主讲内容：
Skin sensitization is a common toxicity endpoint of concern in various industries and accounts for 10-15% of known occupational illness in the U.S. and Europe. Mechanisms of skin sensitization have been investigated intensively for many years and are documented by the Organization for Economic Co-operation and Development (OECD) in its publication, ”The Adverse Outcome Pathway for Skin Sensitization Initiated by Covalent Binding to Proteins”. The adverse outcome pathway (AOP) includes four key mechanistic events: (1) binding of hapten to endogenous proteins in the skin, (2) keratinocyte activation, (3) dendritic cell activation, and (4) proliferation of antigen-specific T cells. The most commonly used animal test, the murine local lymph node assay (LLNA) is based on the understanding of this complex series of events underlying the immune response after expose to a chemical sensitizer, and covers all key events. However, the construction of the AOP for skin sensitization has enabled the development of a multitude of non-animal test methods that are associated with one or more of the AOP key events. However, the complexity of the underlying biology indicates that no single measurement is yet sufficient to predict sensitizer potency. Therefore, it is generally assumed that only a combination of several methods in an integrated testing strategy will obviate the need for animal testing. Many testing strategies combining non-animal methods are developed with defined approaches. The defined approaches are able to either predict skin sensitization hazard (sensitizer versus non-sensitizer) or assign the test substance to one of three skin sensitization potency categories. Here we will introduce an evaluation of defined approaches (DAs) representing non-animal skin sensitization testing strategies performed by the Cosmetics Europe skin tolerance task force and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods.
